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Essential Questions: Progesterone (1)

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Over-The-Counter Hormone Solutions!

What really is Perimenopause?

Perimenopause, the transitional phase leading up to menopause, is characterized by hormonal fluctuations that can bring about various symptoms such as irregular periods, hot flashes, night sweats, mood swings, and sleep disturbances.

Women experiencing both perimenopause and thyroid issues may face compounded challenges, as the symptoms of one condition can intensify those of the other. It is crucial to manage thyroid health during perimenopause to alleviate symptoms and improve overall well-being.

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Main hormonal changes:

  1. Progesterone: Progesterone drops faster in midlife than estrogen. This is what leads to various symptoms including mood swings, sleep disturbances, and irregular menstrual cycles. In perimenopause, estrogen levels are now known to average 30% higher, to be chaotic, and to be associated with less progesterone.

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  1. Estrogen: Research by the UBC Endocrinology’s Centre for Menstrual Cycle and Ovulation Research shows that perimenopausal women may experience heavy flow, sore breasts, and migraine headaches related to higher estrogen levels.

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  1. Pregnenolone: Known as the "mother hormone," pregnenolone is a precursor to many other hormones. As women approach perimenopause, the production of pregnenolone in the body decreases. This decline contributes to the hormonal imbalances that characterize perimenopause, potentially exacerbating symptoms such as mood swings, fatigue, and cognitive changes.

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  1. DHEA: Levels of DHEA peak in early adulthood and begin to decline gradually with age. During perimenopause, the drop in DHEA can contribute to symptoms like decreased libido, reduced energy levels, and a decline in overall well-being. Lower DHEA levels are also associated with decreased bone density and muscle mass.

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  1. Cortisol

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